Anti-CDKN2A Monoclonal Antibody
Printable Datasheet
Synonyms:
ARF, CDK4 inhibitor P16 INK4, CDK4I, CDKN2, CDKN2A, Cell cycle negative regulator beta, CMM2, Cyclin dependent kinase 4 inhibitor A, Cyclin dependent
Entrez Gene ID:
(Murine) 12578
UniProt ID:
P51480
| Details | |
| Host / Isotype: | Rat / IgG2b |
| Class: | Monoclonal |
| Type: | Antibody |
| Clone: | 12-A1-1 |
| Species Reactivity: | Murine (Ms) |
| Immunogen: | Synthetic peptide containing amino acids within 1-100 of the murine p19ARF. |
| Ordering Information | ||||
| Pierce Anti-CDKN2A Monoclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| MA1-16664 | 100 µl | $285.00 | ||
| Storage: | 4º C |
| Form: | 100 µl of raw ascites (4.6 mg/ml) in 0.1% sodium azide. |
| Applications | Dilution |
| Immunofluorescence (IF) | 1:500 |
| Immunoprecipitation (IP) | Assay Dependent |
| Western Blot (WB) | 1:500 |
| Product Specific Information |
| MA1-16664 detects p19ARF in mouse samples. Does not react with human or golden hamster. Armenian hamster has not been tested. MA1-16664 has successfully been used in Western blot, immunoprecipitation, and immunofluorescence applications. The p19ARF molecular weight is ~19 kDa. The MA1-16664 immunogen is amino acids within 1-100 of murine p19ARF. Store at 4ºC short term. For long term storage, aliquot and store at -20ºC. |
| General Information |
| In humans, the multiple tumor suppressor 1 locus (MTS1) encodes two unrelated genes, p16INK4a and p19ARF. Although both act as cell proliferation inhibitors, their mechanisms of action are different. p19ARF works as part of a p53-dependent pathway to counter uncontrolled proliferation and oncogenic signals. Mice lacking the p19ARF gene rapidly develop a broad spectrum of tumors. This result indicates that p19ARF is an important tumor suppressor. In addition, p19ARF helps prevent transforming signals from various onocoproteins via the p53 regulatory loop. These studies and others display the importance of p19ARF in cell cycle control and tumor suppression. |
(This product is for In Vitro experimental use only.)
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Box 117, Rockford, IL 61105 USA |
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