Anti-MMP1 Monoclonal Antibody
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Synonyms:
MMP-1
Entrez Gene ID:
(Human) 4312
UniProt ID:
P03956
| Details | |
| Host / Isotype: | Mouse / IgG1 |
| Class: | Monoclonal |
| Type: | Antibody |
| Clone: | 3B6 |
| Species Reactivity: | Human (Hu) |
| Immunogen: | Synthetic peptide derived from the C-terminus of the human MMP1. |
| Ordering Information | ||||
| Pierce Anti-MMP1 Monoclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| MA1-12891 | 200 µg | $332.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 200 µg of antibody (0.25 mg/ml) in PBS with 0.08% sodium azide. |
| Applications | Dilution |
| Immunohistochemistry (IHC) | 1-5 µg/ml |
| Western Blot (WB) | 1-2 µg/ml |
| Product Specific Information |
| MA1-12891 detects Matrix Metalloproteinase 1 in human samples. MA1-12891 has been successfully used in western blot and immunohistochemistry procedures.Suggested positive controls for this product are colon, oesophageal and gastric tissues. The MA1-12891 immunogen is a synthetic peptide corresponding to human MMP1. |
| General Information |
| The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, fibronectin, laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB). MMP catalysis requires both calcium and zinc. MMP-9 (also designated 92 kDa type IV collagenase or gelatinase B) has been shown to degrade bone collagens in concert with MMP-1 (also designated interstitial collagenase, fibroblast collagenase or collagenase-1), and cysteine proteases and may play a role in bone osteoclastic resorption. MMP-1 is downregulated by p53, and abnormality of p53 expression may contribute to joint degradation in rheumatoid arthritis by regulating MMP-1 expression. |
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Immunohistochemistry with anti-MMP1 Monoclonal Antibody [3B6] (MA1-12891)
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(This product is for In Vitro experimental use only.)
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PO
Box 117, Rockford, IL 61105 USA |
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