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LARGE HEPARAN SULPHATE PROTEOGLYCAN ANTIBODIES > LARGE HEPARAN SULPHATE PROTEOGLYCAN MONOCLONAL ANTIBODY MA1-06821
Anti-Large Heparan Sulphate Proteoglycan Monoclonal Antibody
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Synonyms:
HSPG
Entrez Gene ID:
(Human) 3339
UniProt ID:
P98160
| Details | |
| Host / Isotype: | Rat / IgG2a |
| Class: | Monoclonal |
| Type: | Antibody |
| Clone: | A7L6 |
| Species Reactivity: | Human (Hu) Murine (Ms) Rat (Rt) Bovine (Bv) |
| Immunogen: | High molecular mass material derived from the Engelbreth-Holm-Swarm (EHS) tumor matrix containing laminin, entactin and HSPG. |
| Ordering Information | ||||
| Pierce Anti-Large Heparan Sulphate Proteoglycan Monoclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| MA1-06821 | 100 µg | $342.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 100 µg of antibody (1 mg/ml) in PBS containing 50% glycerol, 0.1% BSA, and 0.02% sodium azide. |
| Applications | Dilution |
| Immunocytochemistry (ICC) | Assay dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | 1:25-1:200 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:25-1:200 |
| Immunoprecipitation (IP) | Assay dependent |
| Western Blot (WB) | 1:100-1:1000 |
| Product Specific Information |
| MA1-06821 detects large heparan sulphate proteoglycan in human, mouse, bovine, and rat samples. MA1-06821 has sucessfully been used in Western blotting, immunocytochemistry, immunoprecipitation, and immunohistochemistry procedures. By Western blot it detects a >400 kDa band representing large HSPG. The MA1-06821 immunogen is a high molecular mass material derived from the Engelbreth-Holm-Swarm (EHS) tumor matrix containing laminin, entactin and HSPG. Figure 1 shows Immunostaining of large heparin sulphate proteoglycan in human skin using MA1-06821. |
| General Information |
| Proteoglycans are macromolecules consisting of a variety of core proteins with covalently attached one or several polysaccharide chains of the glycosaminoglycan type (heparan sulphate, heparin, chondroitin sulphate, dermatan sulphate or keratan sulphate). At least two forms of basement membrane heparan sulphate proteoglycan (HSPG) have been identified. One with a large core protein (>400 kD) and one with a small core protein (~30 kD). The large HSPG is probably the most abundant basement membrane proteoglycan. It is located predominantly in the lamina lucida, where it forms clustered aggregates and interacts with other basement membrane components to form the matrix. In addition, it also plays a critical role in attachment of cells to the basal membrane via integrin receptors. |
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Immunofluorescence with anti-Large Heparan Sulphate Proteoglycan Monoclonal Antibody [A7L6] (MA1-06821)
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(This product is for In Vitro experimental use only.)
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