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E-SELECTIN ANTIBODIES > E-SELECTIN MONOCLONAL ANTIBODY MA1-06505
Anti-E-Selectin Monoclonal Antibody
Printable Datasheet
Synonyms:
CD62E
Entrez Gene ID:
(Murine) 20339
UniProt ID:
Q00690
| Details | |
| Host / Isotype: | Rat / IgG2b |
| Class: | Monoclonal |
| Type: | Antibody |
| Clone: | UZ5 |
| Species Reactivity: | Murine (Ms) |
| Immunogen: | LPS-activated mlEND1 cells expressing E-selectin at their cell surface. |
| Ordering Information | ||||
| Pierce Anti-E-Selectin Monoclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| MA1-06505 | 100 µg | $342.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 100 µg of antibody (1 mg/ml) in PBS with 0.09% sodium azide. |
| Applications | Dilution |
| ELISA (ELISA) | Assay dependent |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay dependent |
| Immunoprecipitation (IP) | Assay dependent |
| Western Blot (WB) | Assay dependent |
| Product Specific Information |
| MA1-06505 detects E-selectin in mouse samples. MA1-06505 has sucessfully been used in Western blotting, immunoprecipitation, immunohistochemistry and ELISA. The MA1-06505 immunogen is LPS-activated mlEND1 cells expressing E-selectin at their cell surface. |
| General Information |
| Leukocytes adhere to the blood vessel endothelium during extravasation in postcapillary venules of lymph nodes. In addition, leukocyte adhesion occurs in the capillaries and small venules at any site in the body after onset of inflammation. This response is immediate and involves a cascade of adhesion receptors. At the endothelial surface members of the selectin and immunoglobulin superfamilies participate in this cascade. Selectins are C-type cell surface lectins that play a role in leukocyte adhesion to the blood vessel wall endothelium. E-selectin (CD62E) is an endothelial cell specific selectin that is expressed only after activation with proinflammatory cytokines. In vitro experiments have shown that IL-1, TNFalpha and bacterial wall components like lipopolysaccharides induce the transcription of E-selectin in a NFkB dependent signalling cascade. E-selectin has been associated with blood vessel endothelium in diverse inflammatory situations. |
(This product is for In Vitro experimental use only.)
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