Anti-CETP Monoclonal Antibody
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Synonyms:
Cholesteryl Ester Transfer Protein, Lipid transfer protein I
Entrez Gene ID:
(Human) 1071
UniProt ID:
P11597
| Details | |
| Host / Isotype: | Mouse / IgG1 |
| Class: | Monoclonal |
| Type: | Antibody |
| Clone: | ATM192 |
| Species Reactivity: | Human (Hu) Rabbit (Rb) |
| Immunogen: | Synthetic peptide corresponding to residues C D(149) S G R V R T D A P D(159) of human CETP protein. |
| Ordering Information | ||||
| Pierce Anti-CETP Monoclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| MA1-050 | 100 µl | $350.00 | ||
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 100 µl of Protein A purified ascites (2 mg/ml) in PBS with 0.05% sodium azide. |
| Applications | Dilution |
| ELISA (ELISA) | Assay dependent |
| Immunoprecipitation (IP) | Assay dependent |
| Western Blot (WB) | 1:400 |
| Product Specific Information |
| MA1-050 detects cholesteryl ester transfer protein (CETP) from human and rabbit tissues. MA1-050 has been successfully used in Western blot, immunoprecipitation, and ELISA protocols. By Western blot, this antibody detects a doublet at ~70 kDa from human serum representing CETP. This antibody can also be used to immunoprecipitate CETP activity from serum samples using protein G. The MA1-050 immunogen is a synthetic peptide corresponding to residues C D(149) S G R V R T D A P D(159) of human CETP protein. Figure 1 illustrates Western blot detection of CETP on human liver extract using MA1-050. |
| General Information |
| It has been proposed that high density lipoproteins (HDLs) function jointly with lecithin:cholesterol acyltransferase and CETP to facilitate cholesterol transport from tissues to the liver. This mechanism, referred to as reverse cholesterol transport, is physiologically important because it maintains systemic cholesterol levels. CETP is responsible for neutral lipid transfer activity in plasma in numerous species. Since CETP is able to accelerate specifically the exchange of lipid components between pro- and anti-atherogenic lipoprotein fractions, it may be a key determinant of the global atherogenicity of the plasma lipoprotein profile and arises as a possible target in atherosclerosis prevention. CETP has an important role in reverse cholesterol transport and shaping and affecting the composition of plasma lipoproteins. In general elevated levels of CETP have been associated with increased risk of coronary heart disease. |
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Western Blot with anti-CETP Monoclonal Antibody [ATM192] (MA1-050)
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| References: |
| Hybridoma 15(5): 359-364, 1996. |
| Biochemica and Biophysica Acta. 1215: 209-236, 1994. |
| Medical Science Research, 21: 911-912, 1993. |
(This product is for In Vitro experimental use only.)
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Box 117, Rockford, IL 61105 USA |
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