Anti-Noggin Polyclonal Antibody
Printable Datasheet
Synonyms:
SYM1, SYNS1
Entrez Gene ID:
(Human) 9241, (Murine) 18121
UniProt ID:
Q13253
| Details | |
| Host / Isotype: | Rabbit / IgG |
| Class: | Polyclonal |
| Type: | Antibody |
| Species Reactivity: | Human (Hu) Murine (Ms) |
| Immunogen: | Synthetic peptide(CEHPDPIFDPKEKD) |
| Ordering Information | ||||
| Pierce Anti-Noggin Polyclonal Antibody | ||||
| Product Number | Pkg. Size | Price | Purchase | |
| LF-PA0092 | 100 µl | $285.00 | ||
This product is not available outside of the U.S.
| Storage: | -20º C, Avoid Freeze/Thaw Cycles |
| Form: | 100 µl of antibody in HEPES with 0.15M NaCl, 0.01% BSA, 0.03% sodium azide, and 50% glycerol |
| Applications | Dilution |
| Western Blot (WB) | Assay Dependent |
| Product Specific Information |
| LF-PA0092 detects Noggin from human, mouse samples. LF-PA0092 has been successfully used in WB procedures. The LF-PA0092 immunogen is a synthetic peptide(CEHPDPIFDPKEKD) |
| General Information |
| The secreted polypeptide, encoded by this gene, binds and inactivates members of the transforming growth factor-beta (TGF-beta) superfamily signaling proteins, such as bone morphogenetic protein-4 (BMP4). By diffusing through extracellular matrices more efficiently than members of the TGF-beta superfamily, this protein may have a principal role in creating morphogenic gradients. The protein appears to have pleiotropic effect, both early in development as well as in later stages. It was originally isolated from Xenopus based on its ability to restore normal dorsal-ventral body axis in embryos that had been artificially ventralized by UV treatment. The results of the mouse knockout of the ortholog suggest that it is involved in numerous developmental processes, such as neural tube fusion and joint formation. Recently, several dominant human NOG mutations in unrelated families with proximal symphalangism (SYM1) and multiple synostoses syndrome (SYNS1) were identified; both SYM1 and SYNS1 have multiple joint fusion as their principal feature, and map to the same region (17q22) as this gene. All of these mutations altered evolutionarily conserved amino acid residues. The amino acid sequence of this human gene is highly homologous to that of Xenopus, rat and mouse. |
(This product is for In Vitro experimental use only.)
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Box 117, Rockford, IL 61105 USA |
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